For "hyaluronic acid", you may know only the tip of the iceberg. An Irreplaceable natural substance in the human body
"Hyaluronic acid, which is hyaluronic acid, is actually a natural component in the human body. It is a natural linear polysaccharide present in human and animal tissues. It is mainly distributed in the vitreous, joint, umbilical cord, skin and other parts of the human body. To play important physiological functions.
Hyaluronic acid is an irreplaceable natural substance in the human body. It is high in the body during embryonic period, and its body content decreases with age. If the relative content of hyaluronic acid in the human body at the age of 20 is 100%, it will decrease to 65%, 45%, 25% at 30, 50, and 60 years old, skin aging, joint deterioration, arteriosclerosis, and old eyes. The symptoms are closely related to the gradual decrease in hyaluronic acid content in the body. The amount of hyaluronic acid contained in the same age group is also different, and the content of the body of the premature aging is significantly reduced, showing many symptoms of aging.
Hyaluronic acid was first discovered in 1934 by Meyer, a professor of ophthalmology at Columbia University in the United States, who first isolated hyaluronic acid from the vitreous vitreous and analyzed its structure. In addition to the bull's eye, the highest content of hyaluronic acid in nature is the cockscomb and the human baby's umbilical cord. In the 1970s, people began to extract hyaluronic acid from the cockscomb. However, the hyaluronic acid extracted from animal tissues has a good effect, but the extraction rate is extremely low, the separation process is complicated, and the yield is limited, which also makes the hyaluronic acid expensive. , up to $5,000 / kg.
In the 1990s, the domestic research on the fermentation technology of hyaluronic acid began to realize industrialization, which ended the backward situation in which China can only use the cockscomb extraction method to produce hyaluronic acid. After more than 20 years of development, the current hyaluronic acid in China The level of fermentation technology, as well as the output and quality have reached the international advanced level, and become the world's largest producer of hyaluronic acid raw materials.
Wide range of applications The entire industry chain is forming
Hyaluronic acid has good physical and chemical properties and biological activity such as water retention, lubricity, viscoelasticity, biodegradability and biocompatibility. At present, with the large-scale industrialization of hyaluronic acid produced by microbial fermentation, the application of hyaluronic acid in medicine, biomedical materials, cosmetics, food and other fields has been greatly popularized and promoted, and gradually expanded to new application fields. Such as tumor treatment, tissue engineering, drug carrier, oral cavity, gastrointestinal, ENT, etc., has expanded the application field of hyaluronic acid, which has greatly promoted the transformation of the industry.
In the field of orthopedics, there are sodium hyaluronate injections for the treatment of knee osteoarthritis and shoulder arthritis; ophthalmology, there are viscoelastics for cataract surgery; surgical, for intracavitary hemostasis, anti-adhesion, and promote wound healing High-end biomedical dressing products. In plastic surgery, there are products for facial filling.
2019 11/23